Ontology highlight
ABSTRACT:
SUBMITTER: Jiang LQ
PROVIDER: S-EPMC6203713 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Jiang Li-Qun LQ Xia Tian T Hu Yun-Hong YH Sun Ming-Shun MS Yan Shuang S Lei Cao-Qi CQ Shu Hong-Bing HB Guo Ji-Hua JH Liu Yu Y
Cellular & molecular immunology 20170424 9
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that can be induced by viral infection and interferons (IFNs). It inhibits the entry and replication of many viruses, which are independent of receptor usage but dependent on processes that occur in endosomes. In this study, we demonstrate that IFITM3 plays important roles in regulating the RNA-virus-triggered production of IFN-β in a negative-feedback manner. Overexpression of IFITM3 inhibited Sendai virus-triggered ind ...[more]