Ontology highlight
ABSTRACT:
SUBMITTER: Lin C
PROVIDER: S-EPMC2749712 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Lin Congxing C Yin Yan Y Chen Hong H Fisher Alexander V AV Chen Feng F Rauchman Michael M Ma Liang L
Genesis (New York, N.Y. : 2000) 20090501 5
Homeobox gene Msx2 is widely expressed during both embryogenesis and postnatal development and plays important roles during organogenesis. We developed an Msx2-rtTA BAC transgenic line which can activate TetO-Cre expression in Msx2-expressing cells upon doxycycline (Dox) treatment. Using the Rosa26-LacZ (R26R) reporter line, we show that rtTA is activated in Msx2-expressing organs including the limb, heart, external genitalia, urogenital system, hair follicles and craniofacial regions. Moreover, ...[more]