Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC2749941 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Li Zhihua Z Lee Insuk I Moradi Emily E Hung Nai-Jung NJ Johnson Arlen W AW Marcotte Edward M EM
PLoS biology 20091006 10
Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. Despite intensive study, this pathway likely involves many additional genes. Here, we employ network-guided genetics-an approach for associating candidate genes with biological processes that capitalizes on recent advances in functional genomic and proteomic studie ...[more]