Ontology highlight
ABSTRACT:
SUBMITTER: Ziegelbauer JM
PROVIDER: S-EPMC2749995 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Ziegelbauer Joseph M JM Sullivan Christopher S CS Ganem Don D
Nature genetics 20081221 1
MicroRNAs (miRNAs) are short noncoding RNAs of cellular and viral origin that post-transcriptionally regulate gene expression through imperfect base pairing to their mRNA targets. Because the recognition sequences of miRNAs for their targets are short and may be discontinuous, bioinformatic prediction of targets is difficult. Here we present an approach to the experimental identification of the mRNA targets of miRNAs encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV encodes 17 ...[more]