Ontology highlight
ABSTRACT:
SUBMITTER: Naim B
PROVIDER: S-EPMC2750018 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Naim Bracha B Zbaida David D Dagan Shlomi S Kapon Ruti R Reich Ziv Z
The EMBO journal 20090813 18
To fulfil their function, nuclear pore complexes (NPCs) must discriminate between inert proteins and nuclear transport receptors (NTRs), admitting only the latter. This specific permeation is thought to depend on interactions between hydrophobic patches on NTRs and phenylalanine-glycine (FG) or related repeats that line the NPC. Here, we tested this premise directly by conjugating different hydrophobic amino-acid analogues to the surface of an inert protein and examining its ability to cross NPC ...[more]