Ontology highlight
ABSTRACT:
SUBMITTER: Ananth AN
PROVIDER: S-EPMC5826291 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Ananth Adithya N AN Mishra Ankur A Frey Steffen S Dwarkasing Arvind A Versloot Roderick R van der Giessen Erik E Görlich Dirk D Onck Patrick P Dekker Cees C
eLife 20180214
Nuclear pore complexes (NPCs) lined with intrinsically disordered FG-domains act as selective gatekeepers for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The underlying physical mechanism of the intriguing selectivity is still under debate. Here, we probe the transport of ions and transport receptors through biomimetic NPCs consisting of Nsp1 domains attached to the inner surface of solid-state nanopores. We examine both wildtype FG-domains and hydrophilic SG-m ...[more]