Ontology highlight
ABSTRACT:
SUBMITTER: Kyle JW
PROVIDER: S-EPMC2752142 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Kyle John W JW Minogue Peter J PJ Thomas Bettina C BC Domowicz Denise A Lopez DA Berthoud Viviana M VM Hanck Dorothy A DA Beyer Eric C EC
Journal of cell science 20080729 Pt 16
The cytoplasmic N-termini of connexins have been implicated in protein trafficking, oligomerization and channel gating. To elucidate the role of the N-terminus in connexin37 (CX37), we studied mutant constructs containing partial deletions of its 23 N-terminal amino acids and a construct with a complete N-terminus in which residues 2-8 were replaced with alanines. All mutants containing nine or more N-terminal amino acids form gap junction plaques in transiently transfected HeLa cells, whereas m ...[more]