Ontology highlight
ABSTRACT:
SUBMITTER: Kelly H
PROVIDER: S-EPMC2752186 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Kelly H H Molony C M CM Darlow J M JM Pirker M E ME Yoneda A A Green A J AJ Puri P P Barton D E DE
Journal of medical genetics 20070727 11
<h4>Background</h4>Vesicoureteric reflux (VUR) is the retrograde flow of urine from the bladder into the ureters. It is the most common urological anomaly in children, and a major cause of end-stage renal failure and hypertension in both children and adults. VUR is seen in approximately 1-2% of Caucasian newborns and is frequently familial.<h4>Objective and methods</h4>In order to search for genetic loci involved in VUR, we performed a genome-wide linkage scan using 4710 single-nucleotide polymo ...[more]