Ontology highlight
ABSTRACT:
SUBMITTER: Cordell HJ
PROVIDER: S-EPMC2799286 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Cordell Heather J HJ Darlay Rebecca R Charoen Pimphen P Stewart Aisling A Gullett Ambrose M AM Lambert Heather J HJ Malcolm Sue S Feather Sally A SA Goodship Timothy H J TH Woolf Adrian S AS Kenda Rajko B RB Goodship Judith A JA
Journal of the American Society of Nephrology : JASN 20091203 1
Primary vesicoureteric reflux accounts for approximately 10% of kidney failure requiring dialysis or transplantation, and sibling studies suggest a large genetic component. Here, we report a whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux and reflux nephropathy. We used linkage and family-based association approaches to analyze 320 white families (661 affected individuals, generally from families with two affected siblings) from two populations (United Ki ...[more]