Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC2752333 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Liu Yan Y Sanoff Hanna K HK Cho Hyunsoon H Burd Christin E CE Torrice Chad C Ibrahim Joseph G JG Thomas Nancy E NE Sharpless Norman E NE
Aging cell 20090522 4
Expression of the p16(INK4a) tumor suppressor sharply increases with age in most mammalian tissues, and contributes to an age-induced functional decline of certain self-renewing compartments. These observations have suggested that p16(INK4a) expression could be a biomarker of mammalian aging. To translate this notion to human use, we determined p16(INK4a) expression in cellular fractions of human whole blood, and found highest expression in peripheral blood T-lymphocytes (PBTL). We then measured ...[more]