Ontology highlight
ABSTRACT:
SUBMITTER: Bazarov AV
PROVIDER: S-EPMC2941554 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Bazarov Alexey V AV Van Sluis Marjolein M Hines William C WC Bassett Ekaterina E Beliveau Alain A Campeau Eric E Mukhopadhyay Rituparna R Lee Won Jae WJ Melodyev Sonya S Zaslavsky Yuri Y Lee Leonard L Rodier Francis F Chicas Agustin A Lowe Scott W SW Benhattar Jean J Ren Bing B Campisi Judith J Yaswen Paul P
Aging cell 20100714 5
The cyclin-dependent kinase inhibitor p16(INK4a) (CDKN2A) is an important tumor suppressor gene frequently inactivated in human tumors. p16 suppresses the development of cancer by triggering an irreversible arrest of cell proliferation termed cellular senescence. Here, we describe another anti-oncogenic function of p16 in addition to its ability to halt cell cycle progression. We show that transient expression of p16 stably represses the hTERT gene, encoding the catalytic subunit of telomerase, ...[more]