Ontology highlight
ABSTRACT:
SUBMITTER: Burgess HA
PROVIDER: S-EPMC2752477 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Burgess H A HA Johnson S L SL Granato M M
Genes, brain, and behavior 20090520 5
The Roundabout (Robo) family of receptors and their Slit ligands play well-established roles in axonal guidance, including in humans where horizontal gaze palsy with progressive scoliosis (HGPPS) is caused by mutations in the robo3 gene. Although significant progress has been made toward understanding the mechanism by which Robo receptors establish commissural projections in the central nervous system, less is known about how these projections contribute to neural circuits mediating behavior. In ...[more]