Ontology highlight
ABSTRACT:
SUBMITTER: Hinkle KM
PROVIDER: S-EPMC3441373 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Hinkle Kelly M KM Yue Mei M Behrouz Bahareh B Dächsel Justus C JC Lincoln Sarah J SJ Bowles Erin E EE Beevers Joel E JE Dugger Brittany B Winner Beate B Prots Iryna I Kent Caroline B CB Nishioka Kenya K Lin Wen-Lang WL Dickson Dennis W DW Janus Christopher J CJ Farrer Matthew J MJ Melrose Heather L HL
Molecular neurodegeneration 20120530
Mutations in the LRRK2 gene are the most common cause of genetic Parkinson's disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in regulating neuronal polarity, neurotransmission, membrane and cytoskeletal dynamics and protein degradation.We created mice lacking exon 41 that encodes the activation hinge of the kinase domain of LRRK2. We have performed a comprehensive analysis of thes ...[more]