Ontology highlight
ABSTRACT:
SUBMITTER: Hiroi T
PROVIDER: S-EPMC2752639 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Arteriosclerosis, thrombosis, and vascular biology 20090806 10
<h4>Objective</h4>Impairment of the thrombomodulin-protein C anticoagulant pathway has been implicated in pathological thrombosis associated with malignancy. Patients who receive proteasome inhibitors as part of their chemotherapeutic regimen appear to be at decreased risk for thromboembolic events. We investigated the effects of proteasome inhibitors on endothelial thrombomodulin expression and function.<h4>Methods and results</h4>Proteasome inhibitors as a class markedly induced the expression ...[more]