Ontology highlight
ABSTRACT:
SUBMITTER: Franchi L
PROVIDER: S-EPMC2754237 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20090619 2
The Nlrp3 inflammasome is critical for the activation of caspase-1 in response to danger signals and particulate matter. However, its role in sterile inflammation remains unclear because prestimulation of phagocytic cells with microbial molecules is required for caspase-1 activation. We show here that exposure of macrophages and dendritic cells to TNF-alpha promotes ATP- or silica-mediated caspase-1 activation and IL-1beta secretion in the absence of microbial stimulation. The effect of TNF-alph ...[more]