Ontology highlight
ABSTRACT:
SUBMITTER: Kuznetsov SG
PROVIDER: S-EPMC2754281 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Kuznetsov Sergey G SG Haines Diana C DC Martin Betty K BK Sharan Shyam K SK
Cancer research 20090120 3
RecA/Rad51 protein family members (Rad51, Rad51b, Rad51c, Rad51d, Xrcc2, and Xrcc3) are essential for DNA repair by homologous recombination, and their role in cancers has been anticipated. Here we provide the first direct evidence for a tumor suppressor function for a member of the Rad51 family. We show that Rad51c deficiency leads to early embryonic lethality, which can be delayed on a Trp53-null background. To uncover the role of Rad51c in tumorigenesis, we have exploited the fact that Rad51c ...[more]