Ontology highlight
ABSTRACT:
SUBMITTER: Veit M
PROVIDER: S-EPMC6712283 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Veit Martin M Ahrens Björn B Seidel Jana J Sommer Anselm A Bhakdi Sucharit S Reiss Karina K
Life science alliance 20190827 5
ADAM17, prominent member of the "Disintegrin and Metalloproteinase" (ADAM) family, controls vital cellular functions through cleavage of transmembrane substrates. Several of these play central roles in oncogenesis and inflammation, yet despite its importance, the mechanism by which ADAM17 is activated is not fully understood. We recently presented evidence that surface exposure of phosphatidylserine (PS) is the penultimate event required for sheddase activation, which occurs upon binding of a me ...[more]