Ontology highlight
ABSTRACT:
SUBMITTER: Lee I
PROVIDER: S-EPMC2755195 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Lee Inhyung I Oh Jee-Hwan JH Shwab E Keats EK Dagenais Taylor R T TR Andes David D Keller Nancy P NP
Fungal genetics and biology : FG & B 20090627 10
Histone deacetylases (HDACs) play an important role in regulation of gene expression through histone modifications. Here we show that the Aspergillus fumigatus HDAC HdaA is involved in regulation of secondary metabolite production and is required for normal germination and vegetative growth. Deletion of the hdaA gene increased the production of several secondary metabolites but decreased production of gliotoxin whereas over-expression hdaA increased production of gliotoxin. RT-PCR analysis of 14 ...[more]