Ontology highlight
ABSTRACT:
SUBMITTER: Chen PC
PROVIDER: S-EPMC2755539 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Chen Po C PC Wharton Rebekah E RE Patel Pratiq A PA Oyelere Adegboyega K AK
Bioorganic & medicinal chemistry 20070825 23
In this study we report the first example of a direct diazo-transfer reaction on readily available 6-aminopenicillanates to give 6-azidopenicillanates in high yield. Subsequent Cu(I)-catalyzed Huisgen cycloaddition between these 6-azidopenicillanates and assorted terminal alkynes facilely furnished 6-triazolylpenicillanic acids. Preliminary biological screening indicates that these triazolylpenicillanic acids possess low to moderate antibacterial activities. ...[more]