Unknown

Dataset Information

0

Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids.


ABSTRACT: In this study we report the first example of a direct diazo-transfer reaction on readily available 6-aminopenicillanates to give 6-azidopenicillanates in high yield. Subsequent Cu(I)-catalyzed Huisgen cycloaddition between these 6-azidopenicillanates and assorted terminal alkynes facilely furnished 6-triazolylpenicillanic acids. Preliminary biological screening indicates that these triazolylpenicillanic acids possess low to moderate antibacterial activities.

SUBMITTER: Chen PC 

PROVIDER: S-EPMC2755539 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Direct diazo-transfer reaction on beta-lactam: synthesis and preliminary biological activities of 6-triazolylpenicillanic acids.

Chen Po C PC   Wharton Rebekah E RE   Patel Pratiq A PA   Oyelere Adegboyega K AK  

Bioorganic & medicinal chemistry 20070825 23


In this study we report the first example of a direct diazo-transfer reaction on readily available 6-aminopenicillanates to give 6-azidopenicillanates in high yield. Subsequent Cu(I)-catalyzed Huisgen cycloaddition between these 6-azidopenicillanates and assorted terminal alkynes facilely furnished 6-triazolylpenicillanic acids. Preliminary biological screening indicates that these triazolylpenicillanic acids possess low to moderate antibacterial activities. ...[more]

Similar Datasets

| S-EPMC9495407 | biostudies-literature
| S-EPMC10107894 | biostudies-literature
| S-EPMC8004608 | biostudies-literature
| S-EPMC8442724 | biostudies-literature
| S-EPMC4479025 | biostudies-literature
| S-EPMC6972035 | biostudies-literature
| S-EPMC6268778 | biostudies-literature
| PRJNA543210 | ENA
| S-EPMC4347599 | biostudies-literature
| S-EPMC3602783 | biostudies-literature