Ontology highlight
ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC8442724 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Chemical science 20210729 35
We have developed a novel copper-catalyzed cyclization of cyclopropenes/diazo compounds and bromodifluoroacetamides, efficiently synthesizing a series of α,α-difluoro-β-lactams in moderate to excellent yields under mild reaction conditions. This reaction represents the first example of [3 + 1] cyclization for the synthesis of β-lactams utilizing a metal carbene intermediate as the C1 synthon. ...[more]