Ontology highlight
ABSTRACT:
SUBMITTER: Hertzel AV
PROVIDER: S-EPMC2755644 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Hertzel Ann V AV Hellberg Kristina K Reynolds Joseph M JM Kruse Andrew C AC Juhlmann Brittany E BE Smith Anne J AJ Sanders Mark A MA Ohlendorf Douglas H DH Suttles Jill J Bernlohr David A DA
Journal of medicinal chemistry 20091001 19
Molecular disruption of the lipid carrier AFABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. Because small molecule inhibitors may be efficacious in defining the mechanism(s) of AFABP/aP2 action, a chemical library was screened and identified 1 (HTS01037) as a pharmacologic ligand capable of displacing the fluorophore 1-anilinonaphthalene 8-sulfonic acid from the lipid binding cavity. The X-ray crystal structure of 1 bound to AFABP/aP2 revealed that th ...[more]