Ontology highlight
ABSTRACT:
SUBMITTER: Reed D
PROVIDER: S-EPMC2856285 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Reed Damon D Shen Ying Y Shelat Anang A AA Arnold Leggy A LA Ferreira Antonio M AM Zhu Fangyi F Mills Nicholas N Smithson David C DC Regni Catherine A CA Bashford Donald D Cicero Samantha A SA Schulman Brenda A BA Jochemsen Aart G AG Guy R Kiplin RK Dyer Michael A MA
The Journal of biological chemistry 20100115 14
The p53 pathway is disrupted in virtually every human tumor. In approximately 50% of human cancers, the p53 gene is mutated, and in the remaining cancers, the pathway is dysregulated by genetic lesions in other genes that modulate the p53 pathway. One common mechanism for inactivation of the p53 pathway in tumors that express wild-type p53 is increased expression of MDM2 or MDMX. MDM2 and MDMX bind p53 and inhibit its function by distinct nonredundant mechanisms. Small molecule inhibitors and sm ...[more]