Ontology highlight
ABSTRACT:
SUBMITTER: Deng X
PROVIDER: S-EPMC2755655 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20090527 34
Ca(2+) signals controlling a vast array of cell functions involve both Ca(2+) store release and external Ca(2+) entry. These two events are coordinated through a dynamic intermembrane coupling between two distinct membrane proteins, STIM and Orai. STIM proteins are endoplasmic reticulum (ER) luminal Ca(2+) sensors that undergo a profound redistribution into discrete junctional ER domains closely juxtaposed with the plasma membrane (PM). Orai proteins are PM Ca(2+) channels that migrate and becom ...[more]