Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC2755672 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Zhang Wen W Yang Jun J Liu Yajuan Y Chen Xi X Yu Tianxin T Jia Jianhang J Liu Chunming C
The Journal of biological chemistry 20090625 34
A central question in Wnt signaling is the regulation of beta-catenin phosphorylation and degradation. Multiple kinases, including CKI alpha and GSK3, are involved in beta-catenin phosphorylation. Protein phosphatases such as PP2A and PP1 have been implicated in the regulation of beta-catenin. However, which phosphatase dephosphorylates beta-catenin in vivo and how the specificity of beta-catenin dephosphorylation is regulated are not clear. In this study, we show that PP2A regulates beta-cateni ...[more]