The genome of the blood fluke Schistosoma mansoni.
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ABSTRACT:
SUBMITTER: Berriman M
PROVIDER: S-EPMC2756445 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
The genome of the blood fluke Schistosoma mansoni.
Berriman Matthew M Haas Brian J BJ LoVerde Philip T PT Wilson R Alan RA Dillon Gary P GP Cerqueira Gustavo C GC Mashiyama Susan T ST Al-Lazikani Bissan B Andrade Luiza F LF Ashton Peter D PD Aslett Martin A MA Bartholomeu Daniella C DC Blandin Gaelle G Caffrey Conor R CR Coghlan Avril A Coulson Richard R Day Tim A TA Delcher Art A DeMarco Ricardo R Djikeng Appolinaire A Eyre Tina T Gamble John A JA Ghedin Elodie E Gu Yong Y Hertz-Fowler Christiane C Hirai Hirohisha H Hirai Yuriko Y Houston Robin R Ivens Alasdair A Johnston David A DA Lacerda Daniela D Macedo Camila D CD McVeigh Paul P Ning Zemin Z Oliveira Guilherme G Overington John P JP Parkhill Julian J Pertea Mihaela M Pierce Raymond J RJ Protasio Anna V AV Quail Michael A MA Rajandream Marie-Adèle MA Rogers Jane J Sajid Mohammed M Salzberg Steven L SL Stanke Mario M Tivey Adrian R AR White Owen O Williams David L DL Wortman Jennifer J Wu Wenjie W Zamanian Mostafa M Zerlotini Adhemar A Fraser-Liggett Claire M CM Barrell Barclay G BG El-Sayed Najib M NM
Nature 20090701 7253
Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families of micro-exon genes that undergo frequent alternative splicing. As the first sequenced flatworm, and a representative of the Lophotrochozoa, it offers insights into early events in the evoluti ...[more]
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