Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni.
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ABSTRACT:
SUBMITTER: Geyer KK
PROVIDER: S-EPMC3265374 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Cytosine methylation regulates oviposition in the pathogenic blood fluke Schistosoma mansoni.
Geyer Kathrin K KK Rodríguez López Carlos M CM Chalmers Iain W IW Munshi Sabrina E SE Truscott Martha M Heald James J Wilkinson Mike J MJ Hoffmann Karl F KF
Nature communications 20110809
Similar to other metazoan pathogens, Schistosoma mansoni undergoes transcriptional and developmental regulation during its complex lifecycle and host interactions. DNA methylation as a mechanism to control these processes has, to date, been discounted in this parasite. Here we show the first evidence for cytosine methylation in the S. mansoni genome. Transcriptional coregulation of novel DNA methyltransferase (SmDnmt2) and methyl-CpG-binding domain proteins mirrors the detection of cytosine meth ...[more]
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