Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC2756616 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Huang Jun J Gong Zihua Z Ghosal Gargi G Chen Junjie J
Molecular cell 20090801 3
Proteins that bind to single-stranded DNA (ssDNA) are essential for DNA replication, recombinational repair, and maintenance of genomic stability. Here, we describe the characterization of an ssDNA-binding heterotrimeric complex, SOSS (sensor of ssDNA) in human, which consists of human SSB homologs hSSB1/2 (SOSS-B1/2) and INTS3 (SOSS-A) and a previously uncharacterized protein C9orf80 (SOSS-C). We have shown that SOSS-A serves as a central adaptor required not only for SOSS complex assembly and ...[more]