Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC2757291 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Li Wei W Sofi M Hanief MH Rietdijk Svend S Wang Ninghai N Terhorst Cox C Chang Cheong-Hee CH
Immunity 20071101 5
MHC class II-expressing double-positive thymocytes induce progression of CD4(+) T cell development as efficiently as cortical thymic epithelial cells do. Because double-positive thymocytes expressing CD1d select natural killer T (NKT) cells, we investigated whether thymocyte-selected CD4(+) (T-CD4) T cells require the same signaling components as NKT cells. Using bone-marrow chimeras, we found that the signaling molecules SAP, Fyn, and PKCtheta were essential for T-CD4 T cell generation, whereas ...[more]