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CD4(+) T cells from MHC II-dependent thymocyte-thymocyte interaction provide efficient help for B cells.

ABSTRACT: Recently, a novel CD4(+) T-cell developmental pathway was reported that generates thymocyte-thymocyte (T-T) CD4(+) T cells. We established a mouse system (CIITA(tg)CIITApIV(-/-)) where thymic positive selection occurred only by major histocompatibility complex (MHC) class II(+) thymocytes. T-T CD4(+) T cells selected via MHC class II-dependent T-T interaction are comprised of PLZF-negative and innate PLZF-positive populations. Until recently, the functional role of the PLZF-negative population was unclear. In this study, we demonstrate that naïve T-T CD4(+) T cells provide B-cell help to a level comparable with that of naïve conventional CD4(+) T cells. Considering the absence of PLZF expression in naïve T-T CD4(+) T cells, these results suggest that PLZF-negative naïve T-T CD4(+) T cells are functionally equivalent to conventional naïve CD4(+) T cells in terms of B-cell help.

SUBMITTER: Kim EJ

PROVIDER: S-EPMC3257047 | biostudies-other | 2011 Nov

REPOSITORIES: biostudies-other

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CD4(+) T cells from MHC II-dependent thymocyte-thymocyte interaction provide efficient help for B cells.

Kim Eun Ji EJ Choi Bomi B Moon Hana H Lee You Jeong YJ Jeon Yoon Kyeong YK Park Seong Hoe SH Kim Tae Jin TJ Jung Kyeong Cheon KC

Immunology and cell biology 20110301 8

Recently, a novel CD4(+) T-cell developmental pathway was reported that generates thymocyte-thymocyte (T-T) CD4(+) T cells. We established a mouse system (CIITA(tg)CIITApIV(-/-)) where thymic positive selection occurred only by major histocompatibility complex (MHC) class II(+) thymocytes. T-T CD4(+) T cells selected via MHC class II-dependent T-T interaction are comprised of PLZF-negative and innate PLZF-positive populations. Until recently, the functional role of the PLZF-negative population w ...[more]

PMID: 21358747

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