Ontology highlight
ABSTRACT:
SUBMITTER: Kemlink D
PROVIDER: S-EPMC2757615 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Kemlink David D Plazzi Giuseppe G Vetrugno Roberto R Provini Federica F Polo Olli O Stiasny-Kolster Karin K Oertel Wolfgang W Nevsimalova Sona S Sonka Karel K Högl Birgit B Frauscher Birgit B Hadjigeorgiou Georgios M GM Pramstaller Peter P PP Lichtner Peter P Meitinger Thomas T Müller-Myshok Bertram B Winkelmann Juliane J Montagna Pasquale P
Neurogenetics 20080110 2
Five loci for restless legs syndrome (RLS) on chromosomes 12q, 14q, 9p, 2q, and 20p (RLS1-RLS5) have been mapped in RLS families, with a recessive in the first and autosomal-dominant mode of inheritance in the latter cases. Investigations of further RLS families showed evidence for genetic locus heterogeneity. We have conducted a genome-wide linkage analysis in a large RLS family of Italian origin with 12 affected members in 3 generations using 5,861 single nucleotide polymorphisms (SNP, 6K Illu ...[more]