Ontology highlight
ABSTRACT:
SUBMITTER: Lal A
PROVIDER: S-EPMC2757794 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Lal Ashish A Navarro Francisco F Maher Christopher A CA Maliszewski Laura E LE Yan Nan N O'Day Elizabeth E Chowdhury Dipanjan D Dykxhoorn Derek M DM Tsai Perry P Hofmann Oliver O Becker Kevin G KG Gorospe Myriam M Hide Winston W Lieberman Judy J
Molecular cell 20090901 5
miR-24, upregulated during terminal differentiation of multiple lineages, inhibits cell-cycle progression. Antagonizing miR-24 restores postmitotic cell proliferation and enhances fibroblast proliferation, whereas overexpressing miR-24 increases the G1 compartment. The 248 mRNAs downregulated upon miR-24 overexpression are highly enriched for DNA repair and cell-cycle regulatory genes that form a direct interaction network with prominent nodes at genes that enhance (MYC, E2F2, CCNB1, and CDC2) o ...[more]