Fast screening of protein surfaces using geometric invariant fingerprints.
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ABSTRACT:
SUBMITTER: Yin S
PROVIDER: S-EPMC2757799 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Fast screening of protein surfaces using geometric invariant fingerprints.
Yin Shuangye S Proctor Elizabeth A EA Lugovskoy Alexey A AA Dokholyan Nikolay V NV
Proceedings of the National Academy of Sciences of the United States of America 20090917 39
We develop a rapid and efficient method for the comparison of protein local surface similarities using geometric invariants (fingerprints). By combining fast fingerprint comparison with explicit alignment, we successfully screen the entire Protein Data Bank for proteins that possess local surface similarities. Our method is independent of sequence and fold similarities, and has potential application to protein structure annotation and protein-protein interface design. ...[more]
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