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One-pot, direct incorporation of [11C]CO2 into carbamates.

ABSTRACT: Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.

SUBMITTER: Hooker JM

PROVIDER: S-EPMC2757932 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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One-pot, direct incorporation of [11C]CO2 into carbamates.

Hooker Jacob M JM Reibel Achim T AT Hill Sidney M SM Schueller Michael J MJ Fowler Joanna S JS

Angewandte Chemie (International ed. in English) 20090101 19

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of (11)CO(2) with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) has been developed for the synthesis of (11)C-labeled carbamates at 75 degrees C within 10 minutes in radiochemical yields above 70% (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications. ...[more]

PMID: 19350593

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