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Acid-Promoted Cascade Reaction of N-(4-Chloroquinolin-3-yl)carbamates with Amines: One-Pot Assembly of Imidazo[4,5-c]quinolin-2-one.

ABSTRACT: An acid-promoted cascade reaction of 4-chloroquinolin-3-yl carbamates with amines is described. This method achieves the formation of two new C-N bonds through an intermolecular amination/intramolecular cyclization reaction sequence. In combination with subsequent Suzuki coupling, this three-component telescopic procedure provides rapid access to various bioactive imidazo[4,5-c]quinolin-2-one derivatives.

SUBMITTER: Lu X

PROVIDER: S-EPMC6292216 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Acid-Promoted Cascade Reaction of N-(4-Chloroquinolin-3-yl)carbamates with Amines: One-Pot Assembly of Imidazo[4,5-<i>c</i>]quinolin-2-one.

Lu Xiao X Kim Myunghoon M Orr Meghan J MJ Li Hao H Huang Wenwei W

European journal of organic chemistry 20180206 13

An acid-promoted cascade reaction of 4-chloroquinolin-3-yl carbamates with amines is described. This method achieves the formation of two new C-N bonds through an intermolecular amination/intramolecular cyclization reaction sequence. In combination with subsequent Suzuki coupling, this three-component telescopic procedure provides rapid access to various bioactive imidazo[4,5-<i>c</i>]quinolin-2-one derivatives. ...[more]

PMID: 30555272

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