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Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions.

ABSTRACT: [reaction: see text] The palladium-catalyzed carboamination of N-protected gamma-aminoalkenes with aryl bromides and triflates has been achieved under new, mild reaction conditions using the weak base Cs(2)CO(3) in dioxane solvent. These reactions tolerate a wide variety of functional groups, including enolizable ketones, nitro groups, methyl esters, and acetates, which are not compatible with previously described conditions.

SUBMITTER: Bertrand MB

PROVIDER: S-EPMC2758105 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions.

Bertrand Myra Beaudoin MB Leathen Matthew L ML Wolfe John P JP

Organic letters 20070201 3

[reaction: see text] The palladium-catalyzed carboamination of N-protected gamma-aminoalkenes with aryl bromides and triflates has been achieved under new, mild reaction conditions using the weak base Cs(2)CO(3) in dioxane solvent. These reactions tolerate a wide variety of functional groups, including enolizable ketones, nitro groups, methyl esters, and acetates, which are not compatible with previously described conditions. ...[more]

PMID: 17249786

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