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Synthesis of cyclic guanidines via Pd-catalyzed alkene carboamination.

ABSTRACT: A new approach to the synthesis of substituted 5-membered cyclic guanidines is described. Palladium-catalyzed alkene carboamination reactions between acyclic N-allyl guanidines and aryl or alkenyl halides provide these products in good yield. This method allows access to a number of different cyclic guanidine derivatives in only two steps from readily available allylic amines.

SUBMITTER: Zavesky BP

PROVIDER: S-EPMC3857308 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Synthesis of cyclic guanidines via Pd-catalyzed alkene carboamination.

Zavesky Blane P BP Babij Nicholas R NR Fritz Jonathan A JA Wolfe John P JP

Organic letters 20131022 21

A new approach to the synthesis of substituted 5-membered cyclic guanidines is described. Palladium-catalyzed alkene carboamination reactions between acyclic N-allyl guanidines and aryl or alkenyl halides provide these products in good yield. This method allows access to a number of different cyclic guanidine derivatives in only two steps from readily available allylic amines. ...[more]

PMID: 24147839

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