Ontology highlight
ABSTRACT:
SUBMITTER: Orozco LD
PROVIDER: S-EPMC2758141 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Orozco Luz D LD Cokus Shawn J SJ Ghazalpour Anatole A Ingram-Drake Leslie L Wang Susanna S van Nas Atila A Che Nam N Araujo Jesus A JA Pellegrini Matteo M Lusis Aldons J AJ
Human molecular genetics 20090731 21
Copy number variants (CNVs) are genomic segments which are duplicated or deleted among different individuals. CNVs have been implicated in both Mendelian and complex traits, including immune and behavioral disorders, but the study of the mechanisms by which CNVs influence gene expression and clinical phenotypes in humans is complicated by the limited access to tissues and by population heterogeneity. We now report studies of the effect of 19 CNVs on gene expression and metabolic traits in a mous ...[more]