Ontology highlight
ABSTRACT:
SUBMITTER: Chaignat E
PROVIDER: S-EPMC3012917 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Chaignat Evelyne E Yahya-Graison Emilie Aït EA Henrichsen Charlotte N CN Chrast Jacqueline J Schütz Frédéric F Pradervand Sylvain S Reymond Alexandre A
Genome research 20101117 1
A preliminary understanding into the phenotypic effect of DNA segment copy number variation (CNV) is emerging. These rearrangements were demonstrated to influence, in a somewhat dose-dependent manner, the expression of genes that map within them. They were also shown to modify the expression of genes located on their flanks and sometimes those at a great distance from their boundary. Here we demonstrate, by monitoring these effects at multiple life stages, that these controls over expression are ...[more]