Ontology highlight
ABSTRACT:
SUBMITTER: Izumchenko E
PROVIDER: S-EPMC2758619 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Izumchenko Eugene E Singh Mahendra K MK Plotnikova Olga V OV Tikhmyanova Nadezhda N Little Joy L JL Serebriiskii Ilya G IG Seo Sachiko S Kurokawa Mineo M Egleston Brian L BL Klein-Szanto Andres A Pugacheva Elena N EN Hardy Richard R RR Wolfson Marina M Connolly Denise C DC Golemis Erica A EA
Cancer research 20090908 18
In the past 3 years, altered expression of the HEF1/CAS-L/NEDD9 scaffolding protein has emerged as contributing to cancer metastasis in multiple cancer types. However, whereas some studies have identified elevated NEDD9 expression as prometastatic, other work has suggested a negative role in tumor progression. We here show that the Nedd9-null genetic background significantly limits mammary tumor initiation in the MMTV-polyoma virus middle T genetic model. Action of NEDD9 is tumor cell intrinsic, ...[more]