Ontology highlight
ABSTRACT:
SUBMITTER: Gebhardt C
PROVIDER: S-EPMC2271015 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Gebhardt Christoffer C Riehl Astrid A Durchdewald Moritz M Németh Julia J Fürstenberger Gerhard G Müller-Decker Karin K Enk Alexander A Arnold Bernd B Bierhaus Angelika A Nawroth Peter P PP Hess Jochen J Angel Peter P
The Journal of experimental medicine 20080121 2
A broad range of experimental and clinical evidence has highlighted the central role of chronic inflammation in promoting tumor development. However, the molecular mechanisms converting a transient inflammatory tissue reaction into a tumor-promoting microenvironment remain largely elusive. We show that mice deficient for the receptor for advanced glycation end-products (RAGE) are resistant to DMBA/TPA-induced skin carcinogenesis and exhibit a severe defect in sustaining inflammation during the p ...[more]