Ontology highlight
ABSTRACT:
SUBMITTER: Ekiert DC
PROVIDER: S-EPMC2758658 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Ekiert Damian C DC Bhabha Gira G Elsliger Marc-André MA Friesen Robert H E RH Jongeneelen Mandy M Throsby Mark M Goudsmit Jaap J Wilson Ian A IA
Science (New York, N.Y.) 20090226 5924
Influenza virus presents an important and persistent threat to public health worldwide, and current vaccines provide immunity to viral isolates similar to the vaccine strain. High-affinity antibodies against a conserved epitope could provide immunity to the diverse influenza subtypes and protection against future pandemic viruses. Cocrystal structures were determined at 2.2 and 2.7 angstrom resolutions for broadly neutralizing human antibody CR6261 Fab in complexes with the major surface antigen ...[more]