Ontology highlight
ABSTRACT:
SUBMITTER: Ekiert DC
PROVIDER: S-EPMC3210727 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Ekiert Damian C DC Friesen Robert H E RH Bhabha Gira G Kwaks Ted T Jongeneelen Mandy M Yu Wenli W Ophorst Carla C Cox Freek F Korse Hans J W M HJ Brandenburg Boerries B Vogels Ronald R Brakenhoff Just P J JP Kompier Ronald R Koldijk Martin H MH Cornelissen Lisette A H M LA Poon Leo L M LL Peiris Malik M Koudstaal Wouter W Wilson Ian A IA Goudsmit Jaap J
Science (New York, N.Y.) 20110707 6044
Current flu vaccines provide only limited coverage against seasonal strains of influenza viruses. The identification of V(H)1-69 antibodies that broadly neutralize almost all influenza A group 1 viruses constituted a breakthrough in the influenza field. Here, we report the isolation and characterization of a human monoclonal antibody CR8020 with broad neutralizing activity against most group 2 viruses, including H3N2 and H7N7, which cause severe human infection. The crystal structure of Fab CR80 ...[more]