Ontology highlight
ABSTRACT:
SUBMITTER: Mar-Heyming R
PROVIDER: S-EPMC2758768 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Mar-Heyming Rebecca R Miyazaki Makoto M Weissglas-Volkov Daphna D Kolaitis Nicholas A NA Sadaat Narimaan N Plaisier Christopher C Pajukanta Päivi P Cantor Rita M RM de Bruin Tjerk W A TW Ntambi James M JM Lusis Aldons J AJ
Arteriosclerosis, thrombosis, and vascular biology 20080313 6
<h4>Objective</h4>Stearoyl-CoA desaturase 1 (SCD1) is the rate-limiting enzyme involved in the synthesis of monounsaturated fatty acids, and in mice SCD1 activity is associated with plasma triglyceride levels. We used the fatty acid desaturation index (the plasma ratio of 18:1/18:0) as a marker of SCD1 activity to investigate the relationship of SCD1 to familial combined hyperlipidemia (FCHL).<h4>Methods and results</h4>The fatty acid desaturation index was measured in 400 individuals from 18 ex ...[more]