Ontology highlight
ABSTRACT:
SUBMITTER: Greggio E
PROVIDER: S-EPMC2759846 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Greggio Elisa E Taymans Jean-Marc JM Zhen Eugene Yuejun EY Ryder John J Vancraenenbroeck Renée R Beilina Alexandra A Sun Peng P Deng Junpeng J Jaffe Howard H Baekelandt Veerle V Merchant Kalpana K Cookson Mark R MR
Biochemical and biophysical research communications 20090903 3
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of inherited Parkinson's disease (PD). The protein is large and complex, but pathogenic mutations cluster in a region containing GTPase and kinase domains. LRRK2 can autophosphorylate in vitro within a dimer pair, although the significance of this reaction is unclear. Here, we mapped the sites of autophosphorylation within LRRK2 and found several potential phosphorylation sites within the GTPase domain. Using mass spectrometry, ...[more]