Ontology highlight
ABSTRACT:
SUBMITTER: Xiong Y
PROVIDER: S-EPMC3701022 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Xiong Yulan Y Dawson Valina L VL Dawson Ted M TM
Biochemical Society transactions 20121001 5
Mutations in the LRRK2 (leucine-rich repeat kinase 2) gene are the most frequent genetic cause of PD (Parkinson's disease), and these mutations play important roles in sporadic PD. The LRRK2 protein contains GTPase and kinase domains and several protein-protein interaction domains. The kinase and GTPase activity of LRRK2 seem to be important in regulating LRRK2-dependent cellular signalling pathways. LRRK2's GTPase and kinase domains may reciprocally regulate each other to direct LRRK2's ultimat ...[more]