Ontology highlight
ABSTRACT:
SUBMITTER: Gambus A
PROVIDER: S-EPMC2760104 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Gambus Agnieszka A van Deursen Frederick F Polychronopoulos Dimitrios D Foltman Magdalena M Jones Richard C RC Edmondson Ricky D RD Calzada Arturo A Labib Karim K
The EMBO journal 20090806 19
The eukaryotic replisome is a crucial determinant of genome stability, but its structure is still poorly understood. We found previously that many regulatory proteins assemble around the MCM2-7 helicase at yeast replication forks to form the replisome progression complex (RPC), which might link MCM2-7 to other replisome components. Here, we show that the RPC associates with DNA polymerase alpha that primes each Okazaki fragment during lagging strand synthesis. Our data indicate that a complex of ...[more]