Ontology highlight
ABSTRACT:
SUBMITTER: Oksenych V
PROVIDER: S-EPMC2760107 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Oksenych Valentyn V Bernardes de Jesus Bruno B Zhovmer Alexander A Egly Jean-Marc JM Coin Frédéric F
The EMBO journal 20090827 19
XPB and XPD subunits of TFIIH are central genome caretakers involved in nucleotide excision repair (NER), although their respective role within this DNA repair pathway remains difficult to delineate. To obtain insight into the function of XPB and XPD, we studied cell lines expressing XPB or XPD ATPase-deficient complexes. We show the involvement of XPB, but not XPD, in the accumulation of TFIIH to sites of DNA damage. Recruitment of TFIIH occurs independently of the helicase activity of XPB, but ...[more]