Ontology highlight
ABSTRACT:
SUBMITTER: Mortusewicz O
PROVIDER: S-EPMC2592824 | biostudies-other | 2008 Dec
REPOSITORIES: biostudies-other
Mortusewicz Oliver O Roth Wera W Li Na N Cardoso M Cristina MC Meisterernst Michael M Leonhardt Heinrich H
The Journal of cell biology 20081201 5
The multifunctional nuclear protein positive cofactor 4 (PC4) is involved in various cellular processes including transcription, replication, and chromatin organization. Recently, PC4 has been identified as a suppressor of oxidative mutagenesis in Escherichia coli and Saccharomyces cerevisiae. To investigate a potential role of PC4 in mammalian DNA repair, we used a combination of live cell microscopy, microirradiation, and fluorescence recovery after photobleaching analysis. We found a clear ac ...[more]