Ontology highlight
ABSTRACT:
SUBMITTER: Park HJ
PROVIDER: S-EPMC2760115 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Park Hyun Jung HJ Carr Janai R JR Wang Zebin Z Nogueira Veronique V Hay Nissim N Tyner Angela L AL Lau Lester F LF Costa Robert H RH Raychaudhuri Pradip P
The EMBO journal 20090820 19
The transcription factor FoxM1 is over-expressed in most human malignancies. Although it is evident that FoxM1 has critical functions in tumour development and progression, the mechanisms by which FoxM1 participates in those processes are not understood. Here, we describe an essential role of FoxM1 in the regulation of oxidative stress that contributes to malignant transformation and tumour cell survival. We identify a negative feedback loop involving FoxM1 that regulates reactive oxygen species ...[more]