Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC4364948 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Jin Yang Y Wang Ling L Qu Su S Sheng Xia X Kristian Alexandr A Mælandsmo Gunhild M GM Pällmann Nora N Yuca Erkan E Tekedereli Ibrahim I Gorgulu Kivanc K Alpay Neslihan N Sood Anil A Lopez-Berestein Gabriel G Fazli Ladan L Rennie Paul P Risberg Bjørn B Wæhre Håkon H Danielsen Håvard E HE Ozpolat Bulent B Saatcioglu Fahri F
EMBO molecular medicine 20150301 3
The six transmembrane protein of prostate 2 (STAMP2) is an androgen-regulated gene whose mRNA expression is increased in prostate cancer (PCa). Here, we show that STAMP2 protein expression is increased in human PCa compared with benign prostate that is also correlated with tumor grade and treatment response. We also show that STAMP2 significantly increased reactive oxygen species (ROS) in PCa cells through its iron reductase activity which also depleted NADPH levels. Knockdown of STAMP2 expressi ...[more]